Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact between the endoplasmic reticulum (ER) and plasma membrane (PM).This is believed to be caused by transport of PI4P from the PM to the ER, where PI4P is degraded by an Wardrobe ER-
Continued rise in incidence and prevalence of diabetes globally warrants an effective strategy for its prevention and control.Prevention of diabetes seems more logical to attempt seeing its health care burden, long dormancy, systemic affliction and poor general awareness.Pre-diabetes is the intermediate state of erratic glucose metabolism without o
Cells generate diverse microtubule populations by polymerization of a common alpha/beta-tubulin building block.How microtubule associated proteins translate microtubule heterogeneity into specific cellular functions is not clear.We evaluated the ability of kinesin motors involved in vesicle transport to read microtubule heterogeneity by using singl
Abstract Introduction Leiomyosarcomas are neoplasms of smooth muscles that most commonly arise from the uterus, gastrointestinal tract, or soft tissue.Primary pleural leiomyosarcoma is extremely rare.To the best of our knowledge, only nine cases have been published to date.Because of the rarity of pleural leiomyosarcoma and its similarity (clinical
Abstract Central exclusive and semiexclusive production of pairs is measured with the CMS detector in proton-proton collisions at the LHC at center-of-mass energies of 5.02 and 13TeV.The theoretical description of these nonperturbative processes, which Garlic Press have not yet been measured in detail at the LHC, poses a significant challenge to mo